How do ED Pills work? Explaining the entire mechanism

Blake Jones

New Member
Erectile Dysfunction is the inability of a man to have firm erections for sexual intercourse. The disorder is also termed impotency. Around 1 in every 5 men globally suffer from Erectile Dysfunction but the stats go unreported because a majority of them hide the problem and refuse to take any action in curing it.

While the need of the hour is to normalize talking about sex and its related problems, it is also quite important for the men suffering from it to know that expressing about their ED and not stressing about it is a much better solution than stressing over it for the rest of your life. Also, seeking the right treatment option is a must for ED before it gets too late.

While we know what Erectile Dysfunction is, not many of us are aware of the science and the mechanism behind it that how the problem is actually triggered, how it progresses, and how it turns into a severe complication if not given proper attention to and a slight overview of the basic treatment methods which can work in curing your ED. Let us dive into detail with the mechanism, pathophysiology, and causes of Erectile Dysfunction.

A typical penile erection involves psychological, neurological, biological, and anatomical processes. Certain neurovascular events take place during the erection that eventually stimulates the release of noradrenergic neurotransmitter, nitric oxide. The process of complete neurovascular events is beyond the scope of this article. The nitric oxide released triggers the factors responsible for increased levels of cyclic guanosine monophosphate (cGMP). This cGMP results in the relaxation of the smooth muscles, enriching the arterial blood flow thus stimulating firm erection for sexual activity.

Risk factors associated with ED
Erectile Dysfunction is not a single way disorder. There are many risk factors concerned with it that can trigger ED or can become the aftereffect of an ED.

Causes of Erectile Dysfunction
Physiological factors
  • Diabetes
  • High blood pressure and cholesterol
  • Kidney or liver damage
  • Hormonal Imbalances
  • Cardiovascular disorders
  • Obesity

Psychological factors
  • Stress
  • Depression
  • Trauma
  • Anxiety
  • Frustration

Lifestyle factors
  • No work-life balance
  • Poor dietary pattern
  • Substance abuse
  • Lack of physical activity

Treating ED
Lifestyle modifications
Your lifestyle and your daily routine signify a lot of what's happening inside your body. If you do not perform even a single physical exercise in a day, and usually feel tired and inactive, these factors can come into play with triggering ED. Lots of junk food, alcohol, drugs, smoking, etc. are also the prime factors you may have an ED. So, it is advised to consume a balanced diet with healthy foods rich in nutrients to incorporate into your diet. Stay away from substance abuse and bring physical activity into your routine.

Behavioral cognitive therapy
Someone rightly said- What we think, we become. Your thoughts control every ounce of what functions in your body. Stress, anxiety, depression, negative thoughts disturb your mental state and bring about hormonal alterations. This can eventually trigger ED. So, stay positive and happy as much as possible. Invest your thoughts in creating the best version of yourself. Even if you have ED, do not stress about it. Work towards the problem in a disciplined manner and you will get through it eventually.

ED medications
ED Medicines or pills are known to be the frontline primary treatment options for Erectile Dysfunction. There are many medicines available in the market, even their generic forms, which are quite effective, safe, and budget-friendly. Some of these ED medicines include Sildenafil, Vidalista, Fildena, etc. Apart from what we know about these ED medications regarding their dosage, sign and symptoms, precautions, etc, the main concept is still unknown to many which is the mechanism of these pills in curing your Erectile Dysfunction. So, here, taking an example of one of the most trusted, effective, and widely used ED medicine Vidalista to explain the science behind the working of an ED medication.

As mentioned above in the article, cGMP allows easy blood flow to the penile tissues that are known to stimulate an erection. But in the course of this process, an enzyme known as Phosphodiesterase (PDE5) blocks the flow of the blood towards the penis by breaking down cGMP thus subsiding the erection.

Vidalista is a tablet or a medicine primarily used to treat erectile dysfunction in men. It also treats symptoms of benign prostatic hypertrophy (enlarged prostate). It encompasses a generic drug called Tadalafil which inhibits the PDE5 enzyme from destroying cGMP ( the factor responsible for blood flow towards the penis and thus maintaining an erection).

Vidalista is also called the "weekend pill" as it is taken once a week, unlike other ED medications which are taken every day. One dose is taken in a week 30 minutes before your sexual with lots of water. Vidalista starts working in 10-15 minutes and stays in the body for 36-48 hours and that's the reason it doesn't need to be consumed on a daily basis. Avoid overdosing and multiple dosing of Vidalista to prevent any further complications.

Like other ED pills, Vidalista also comes with side effects which are as follows-
  • flushing
  • nausea
  • vomiting
  • hearing impairment
  • blurred vision
  • chest pain
  • upset stomach
  • painful erection

Avoid the intake of high fatty foods if you are on the course of Vidalista. Also avoid grapefruit juices, alcohol, and nitrate derivatives. Do not involve in activities that require mind working while on Vidalista like driving. Do not consume the medicine if you are pregnant. People with other ongoing health issues also should not consume Vidalista.

Store Vidalista in a cool, dark, and dry place with strict prevention to exposure to sunlight and humid conditions. This is a general storage rule for nearly all ED medications.

Surgery is yet another option to cure erectile dysfunction. But this is the last resort option if the medications do not work and the problem of ED is way too severe. There are vacuum implants, ED rings, muscular vascularization techniques involved in surgeries.