Hi Aim4C. I've been taking PM for over 5 years now. I originally began on it for my health since I was coming off a very serious Flu and subsequent bronchitis. It was recommend to me by a Chinese friend who happened to mention...by the way, if you want bigger boobs, this'll do it. At the time I just wanted to get well again. I started it as soon as I got the tablets, but after I had finished with my anti-biotics. There was no need to cleanse. I have never had any problems with it. In the first year I got back all my lost weight and increased from a 'skinny' B, due to weight loss, to a nice healthy C. I liked the results, began Noogling...still taking two PMs a day.... and grew to a D. Dropped back to taking only one PM a day, began using the XL Domes and am now an E. Despite what people have said about taking a break during your period, I have never stopped taking my daily dosage and have had no ill effects at all. By the way...you made a good choice of PM capsules. I've had some from that company myself.